Graham-Cassidy proposal: What you need to know

The latest Republican legislation attempting to “repeal and replace” the Affordable Care Act drafted by Senators Lindsey Graham (R-S.C.) and Bill Cassidy, MD, (R-La.), and thus deemed the Graham-Cassidy proposal, has gained growing disapproval from several health care organizations, including the AMA and the American College of Physicians. Within the past week, the AMA and the American College of Physicians (ACP) sent separate letters to the Senators conveying their strong opposition to the bill, citing as main concerns the loss of health care insurance for millions of Americans and its failure to “first, do no harm” to patients. The associations also urged the Senate to reject the legislation and reiterated recommendations to ensure affordable, quality coverage that is accessible to all patients across the country.Original Article


Poor clinical response in RA yields short-term risk for type 2 diabetes

Patients with rheumatoid arthritis who have a poor clinical response had a significant short-term risk for developing type 2 diabetes, according to results published in PLOS ONE.Researchers collected demographic characteristics, smoking habits, RA features and complications, comorbidities and medications used among 439 patients with RA at study entry and after 12-month follow-up. Researchers categorized patients as underweight, normal weight, overweight or obese, and assessed disease activity using the DAS28.Original Article


FDA finalizes guidelines on interoperable devices

The FDA recently issued final guidelines outlining its nonbinding recommendations for safe and secure interactions among medical devices and other information systems, calling for devices to be designed with interoperability as an objective.The guideline is intended to highlight what medical device manufacturers should consider to provide a “reasonable assurance of safety and effectiveness” for their interoperable medical devices, and provides manufacturers with design considerations and recommendations regarding information to include in premarket submissions and device labeling.Original Article


Major physician groups urge Senate to stabilize health insurance markets

A coalition of major physician groups submitted a testimony to the Senate Health, Education, Labor and Pensions Committee emphasizing the importance of stabilizing health insurance markets to ensure that patients have access to a variety of affordable and comprehensive health insurance coverage options.The coalition consisted of the American College of Physicians (ACP), the American Academy of Family Physicians, the American Academy of Pediatrics, the American Congress of Obstetricians and Gynecologists, the American Osteopathic Association and the American Psychiatric Association.Original Article


Cardiovascular, Renal Outcomes in Type 1 Diabetes

Anna Olechowska

September 21, 2017

Cardiovascular, Renal Outcomes in Type 1 Diabetes
This article originally appeared here.

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More awareness for afib risk factors including age, severity of complications, and glycemic status are needed.
More awareness for afib risk factors including age, severity of complications, and glycemic status are needed.

Patients with type 1 diabetes are at an increased risk for atrial fibrillation (AF), and the risk is greater in women than in men, according to a recent study published in the Lancet Diabetes and Endocrinology.

In the first prospective study investigating the connection between AF and type 1 diabetes, Sofia Dahlqvist, from the Department of Medicine at the NU Hospital Group in Uddevalla, Sweden, and colleagues gathered data on 36,258 patients with type 1 diabetes and 179,980 individuals without diabetes from the Swedish National Diabetes Register and the Swedish National Patient Registry. Researchers calculated the incidences of AF through sex, age, glycemic control (as measured by mean glycated hemoglobin [HbA1C]), and renal complication (assessed via normoaluminuria and microaluminuria) variables.

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During the follow-up period of 9.7 years for the type 1 diabetes group and 10.2 years for the control group, 749 participants with diabetes (2%) and 2882 control participants (2%) were diagnosed with AF, with an adjusted hazard ratio (HR) of 1.13 in men (95% CI, 1.01-1.25; P =.029) and an HR of 1.50 in women (95% CI, 1.30-1.72; P <.0001).

The researchers noted differences between increased risk and sex and completed further analyses for men and women separately. In an age-adjusted analysis, the HR for AF was 1.29 in men with type 1 diabetes (95% CI, 1.16-1.43; P <.0001) and 1.74 in women with type 1 diabetes (95% CI, 1.52-1.98; P <.0001). The risk for AF in men aged 35 to 49 years was 1.42 (95% CI, 1.10-1.84; P =.0075), which was higher than in men aged 18 to 34 years, 50 to 64 years, or 65 years or older. Women aged 50 to 64 years (95% CI, 1.60; 95% CI, 1.27-2.03; P <.0001) and 65 years and older (HR, 1.34; 95% CI, 1.12-1.62; P =.0019) had higher risk for AF, whereas younger women had no increased risk.

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Patients with worsening glycemic control or higher HbA1C (defined as values of ≥9.7% [≥83 mmol/mol]) also had an increased risk for AF; in men, the HR was 2.20 (95% CI, 1.60-3.02; P <.0001) vs 2.62 in women (95% CI, 1.72-3.98; P <.0001).

AF risk was significantly increased for women with renal complications. Individuals with normoalbuminuria had an increased HR of 1.32 (95% CI, 1.10-1.57; P =.0023), and those with microalbuminuria had an increased HR of 1.58 (95% CI, 1.17-2.12; P =.0028). AF risk was not increased in men with normoalbuminuria or microalbuminuria.


Antidiabetics Market to surpass $110 Billion by 2024: Global Market Insights, Inc. - GlobeNewswire (press release)

Antidiabetics Market to surpass $110 Billion by 2024: Global Market Insights, Inc.
GlobeNewswire (press release)
Type 2 diabetes mellitus (T2DM) has strong familial aggregation, the person with a parent or sibling with disease are at high risk. People with obesity, hypertension, or dyslipidemia and women with history of gestational diabetes are also at high risk ...
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