More Democrats than Republicans OK with how media covers science

More Democrats than Republicans think the news media does a good job of covering science, according to the results of a new study.The Pew Research Center polled more than 4,000 U.S. adults and found that although most — 54% — regularly get their science news from general news outlets that cover a range of topics, just 28% believed these sources get the facts right. Specialty sources, including museums, science magazines and documentaries, were trusted more, with around half of respondents saying they are accurate most of the time.Original Article


Hepatitis C Increases Miscarriages, Pregnancy Risks - MD Magazine (registration) (blog)

MD Magazine (registration) (blog)
Hepatitis C Increases Miscarriages, Pregnancy Risks
MD Magazine (registration) (blog)
Women with the hepatitis C virus (HCV) have fewer live births and face a higher risk of miscarriage, infertility, gestational diabetes and pre-eclampsia during pregnancy, researchers in Italy have found. HCV-positive women of childbearing age undergo ...
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AMA urges Senate to reject Graham-Cassidy proposal

The AMA recently sent a letter to Senate Majority Leader Mitch McConnell and Minority Leader Charles Schumer strongly opposing the Graham-Cassidy legislation, emphasizing that the bill would result in the loss of health insurance coverage for millions of Americans while destabilizing health insurance markets.“Similar to proposals that were considered in the Senate in July, we believe the Graham-Cassidy Amendment would result in millions of Americans losing their health insurance coverage, destabilize health insurance markets, and decrease access to affordable coverage and care,” James L. Madara, MD, CEO and executive vice president of AMA, wrote in the letter.Original Article


Hypocalcemia risk comparable between denosumab, oral bisphosphonate

Incidence rates of hypocalcemia in women with postmenopausal osteoporosis are comparable between those treated with denosumab or bisphosphonate monotherapy and the rate of hypocalcemia among those treated with denosumab is consistent with the labeled risk, study data show. Leslie Spangler, PhD, of the Center for Observational Research at Amgen, and colleagues evaluated administrative data from U.S. Medicare (2010-2013) on 3,973,567 women (50% aged 75 years) with postmenopausal osteoporosis to report on incidence rates of events with expected early onsets including hypocalcemia, dermatologic events, hypersensitivity, serious infection and acute pancreatitis. Follow-up was a mean of 2.5 years.Original Article


Biomarker may predict preeclampsia risk in women with type 1 diabetes

Pregnancy outcomes in women with childhood-onset type 1 diabetes are commonly poor, and a new biomarker could help predict which women may develop preeclampsia, according to two studies presented at the European Association for the Study of Diabetes Annual Meeting. In the first study, Chris Watson, PhD, of the Centre for Experimental Medicine at Queen’s University Belfast in the United Kingdom, and colleagues evaluated data from the MAMPED cohort on 62 pregnant women with type 1 diabetes who did (n = 23) or did not (n = 21) develop preeclampsia and 18 healthy controls. Participants with diabetes were matched for age, disease duration, HbA1c levels and parity.Original Article


Lowering Heart Failure Hospitalizations in T2D: SGLT2 vs DPP4 Inhibitors

Brandon May

September 20, 2017

Lowering Heart Failure Hospitalizations in T2D: SGLT2 vs DPP4 Inhibitors
This article originally appeared here.

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SLGT2 inhibitors were more effective even in patients with complications from diabetes.
SLGT2 inhibitors were more effective even in patients with complications from diabetes.

Hospital admissions for heart failure (HF) are lower in older patients with type 2 diabetes (T2D) treated with sodium-glucose co-transporter-2 (SGLT2) vs dipeptidyl peptidase-4 (DPP4) inhibitors, according to a real-world, retrospective analysis published in Cardiovascular Diabetology.1

The researchers retrospectively examined outcomes in patients with T2D using a national commercially insured claims database, specifically comparing patients receiving either SGLT2 (n=4899) or DPP4 (n=9798) medications. Primary outcome, assessed with Cox regression models, was HF hospitalization.

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Following risk adjustment, patients receiving SGLT2 inhibitors had significantly lower rates of hospitalization due to HF compared with DPP4 users (2.0% vs 3.1%, respectively; adjusted hazard ratio [aHR], 0.68; 95% CI, 0.54-0.86; P =.001). In patients aged 65 years or older, HF hospitalization rates were also lower in the SGLT2 cohort vs the DPP4 cohort (4.7% vs 9.1% DPP4; aHR, 0.60; 95% CI, 0.41-0.87; P =.008).

In addition, patients presenting with a diabetes complication who also received SGLT2 medications had lower rates of hospital admissions for HF compared with the DPP4 group (4.5% vs 6.9%; aHR, 0.68; 95% CI, 0.52-0.90; P =.006).

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Because this study compared outcomes of nonrandomized treatment groups, there may have been potential selection bias. Also, there was a lack of information regarding diabetes onset or duration in claims data, which may have affected outcomes.

To establish greater clarity on this study's findings, the investigators commented that future studies “could focus on comparisons of the SGLT2 class with other antidiabetic drug classes to further confirm the potential class level effect of SGLT2 drugs.”


Gautam S, Agiro A, Barron J, Power T, Weisman H, White J. Heart failure hospitalization risk associated with use of two classes of oral antidiabetic medications: an observational, real-world analysis. Cardiovasc Diabetol. 2017;16(1):93. doi:10.1186/s12933-017-0575-x

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